Both have enjoyed their fair share of success, and both have produced a dazzling array of talent that has gone on to achieve great things in the game.
With the two sides meeting in the Premier League for the first time in 17 years on Friday evening, we’ve taken a look through the history books to pick out some of their most scintillating clashes.
Click and scroll through the pages below.
1. Leeds United 2-1 West Ham, February 2005
Not the highest-scoring encounter between the two sides, but a stunning late win for Leeds nonetheless. Shaun Derry wasn't exactly blessed with an eye for goal, but he popped up with five minutes to go to snatch all three points for the Whites in this Championship clash. (Photo by Gary M.Prior/Getty Images) Photo: Gary M. Prior
2. Leeds United 2-2 West Ham, August 2011
Another Championship clash, another late Leeds goal. This time it was the turn of Adam Clayton to play the hero, bagging himself a last minute equaliser at Upton Park. (Photo by Dean Mouhtaropoulos/Getty Images) Photo: Dean Mouhtaropoulos
3. Leeds United 3-0 West Ham
Leeds came flying out of the blocks on New Year's Day 2002, with Mark Viduka scoring two in the first seven minutes to leave West Ham reeling. Robbie Fowler was on target in the second half to put this one to bed and give the Whites all three points. (Photo By Ben Radford/Getty Images) Photo: Ben Radford
4. Leeds United 3-2 West Ham, March 1990
New boy Lee Chapman was the hero and the villain of this topsy-turvy clash in early 1990. The striker scored an own goal against his future employers, but redeemed himself fully with a brace. Gordon Strachan chipped in with a third. (Photo by Mike Hewitt/Allsport) Photo: Mike Hewitt
5. Leeds United 4-1 West Ham, November 1973
West Ham still boasted some big names in the early '70s, including Bobby Moore, Trevor Booking, and a certain Frank Lampard Snr., but goals from Allan Clarke, Mick Bates, and a brace from Mick Jones were enough to wrap up a thumping win for Leeds. (Photo by Ted West/Central Press/Getty Images) Photo: Ted West
6. Leeds United 4-0 West Ham, December 1998
Leeds' had a young, exciting crop of talent in the late '90s, and the Hammers had no answer to their exuberance in early December 1998. The Whites ran riot against an impressive West Ham lineup, with Robert Molenaar, Jimmy Floyd Hasselbaink, and a Lee Bowyer double doing the business at Elland Road. (Photo by Ben Radford /Allsport). Photo: Ben Radford